Quorum-sensing regulation of virulence factors in bacterial biofilm

Warrier, Anjali and Satyamoorthy, K and Murali, TS (2021) Quorum-sensing regulation of virulence factors in bacterial biofilm. Future Microbiology, 16. pp. 1003-1021. ISSN 1746-0913

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Abstract

Chronic polymicrobial wound infections are often characterized by the presence of bacterial biofilms. They show considerable structural and functional heterogeneity, which influences the choice of antimicrobial therapy and wound healing dynamics. The hallmarks of biofilm-associated bacterial infections include elevated antibiotic resistance and extreme pathogenicity. Biofilm helps bacteria to evade the host defense mechanisms and persist longer in the host. Quorum-sensing (QS)-mediated cell signaling primarily regulates biofilm formation in chronic infections and plays a major role in eliciting virulence. This review focuses on the QS mechanisms of two major bacterial pathogens, Staphylococcus aureus and Pseudomonas aeruginosa and explains how they interact in the wound microenvironment to regulate biofilm development and virulence. The review also provides an insight into the treatment modalities aimed at eradicating polymicrobial biofilms. This information will help us develop better diagnostic modalities and devise effective treatment regimens to successfully manage and overcome severe lifethreatening bacterial infections.

Item Type: Article
Uncontrolled Keywords: Biofilm ; polymicrobial infection ; quorum sensing ; virulence.
Subjects: Departments at MU > Public Health
Life Sciences > MLSC Manipal
Depositing User: KMC Library
Date Deposited: 09 Dec 2021 04:29
Last Modified: 09 Dec 2021 04:29
URI: http://eprints.manipal.edu/id/eprint/157799

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