Protein Profile Study of Clinical Samples using Laser Induced Fluorescence as the Detection Method: Case of Malignant And Normal Cervical Tissues

Karemore, Gopal and Rai, Lavanya and Kartha, VB and Santhosh, C (2011) Protein Profile Study of Clinical Samples using Laser Induced Fluorescence as the Detection Method: Case of Malignant And Normal Cervical Tissues. Proc. of SPIE.

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Abstract

Protein profiles of tissue homogenates were recorded using HPLC separation and LIF detection method. The samples were collected from volunteers with clinically normal or cervical cancer conditions. It is shown that the protein profile can be classified as belonging to malignant or normal state by using hard and Fuzzy clustering methods. The study was performed to test the utility of the HPLC-LIF protein profiling method for classification of tissue samples as well as to establish a complementary method for histopathology for clinical diagnosis of the tissue as normal or malignant.

Item Type: Article
Uncontrolled Keywords: Protein profile, HPLC-LIF, Cervical cancer, Tissue homogenates, Data classification, Fuzzy clustering
Subjects: Departments at MU > Atomic Molecular Physics
Medicine > KMC Manipal > Obstetrics & Gynaecology
Depositing User: KMC Manipal
Date Deposited: 26 Oct 2011 04:36
Last Modified: 26 Oct 2011 04:36
URI: http://eprints.manipal.edu/id/eprint/1578

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