An insight on promising strategies hoping to cure HIV‑1 infection by targeting Rev protein—short review

Pai, Sahana and Mudgal, Jayesh and Kamath, Venkatesh B and Pai, Sreedhara Ranganath K (2021) An insight on promising strategies hoping to cure HIV‑1 infection by targeting Rev protein—short review. Pharmacological Reports, 73. pp. 1265-1272. ISSN 1734-1140

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Abstract

Human immunodefciency virus-1 (HIV-1) infection remains to be one of the major threats throughout the world. Many researchers are working in this area to fnd a cure for HIV-1. The group of the FDA approved drugs which are currently used against HIV-1 in the clinical practice include nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), integrase inhibitors (InIs), and protease inhibitors (PIs). Fixed dose combinations (FDCs) of these drugs are available and are used as per the anti-retroviral therapy (ART) guidelines. Despite these, unfortunately, there is no cure for HIV1 infection to date. The present review is focused upon describing the importance of a post-transcriptional regulatory protein “Rev”, responsible for latent HIV-1 infection as a possible, and promising therapeutic target against HIV-1

Item Type: Article
Uncontrolled Keywords: Rev protein; HIV-1 infections; ABX464; Latent HIV-1 infection
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Biotechnology
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 09 Dec 2021 04:28
Last Modified: 09 Dec 2021 04:28
URI: http://eprints.manipal.edu/id/eprint/157812

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