Implications of phase solubility/miscibility and drug-rich phase formation on the performance of co-amorphous materials: The case of Darunavir co-amorphous materials with Ritonavir and Indomethacin as co-formers

Shete, Sushant and Reddy, Sai Charan and Yarlagadda, Dani Lakshman and Vullendula, Sai Krishna Anand and Mehta, Chetan Hasmukh and Nayak, Usha Yogendra and Dengale, Swapnil J (2021) Implications of phase solubility/miscibility and drug-rich phase formation on the performance of co-amorphous materials: The case of Darunavir co-amorphous materials with Ritonavir and Indomethacin as co-formers. International Journal of Pharmaceutics, 608. pp. 1-13. ISSN 0378-5173

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Abstract

The present study was designed to investigate the contribution of solid-state and the impact of composite drugrich phase generated as a consequence of pH shift on the maximum achievable supersaturation of co-amorphous formulations. The co-amorphous phases of weak base-weak base-pair i.e. Ritonavir and Darunavir were prepared in anticipation of studying the effect of drug-rich phase consequent to pH shift. While the co-amorphous phases of weak base-Weak acid pair i.e. Darunavir and Indomethacin were studied to understand the manifestation of the solid-state drug: co-former miscibility in the absence of drug rich phase. Thermodynamically, the lowering of the supersaturation was found commensurate with the mole fraction of the respective component (Drug/Coformer) within the co-amorphous materials for both Darunavir: Ritonavir and Darunavir: Indomethacin pair.Kinetically, for Darunavir: Ritonavir co-amorphous materials, the shift in the pH from acidic to the neutral side led to the generation of drug-rich phase and subsequent LLPS. The free drug concentration achieved in the bulk of the solution was found dependent upon the mole fraction of the respective component within the drug-rich phase. The relative mole fraction of each component within the composite drug-rich phase is dictated by pHdependent solubility and molecular weight of the individual components

Item Type: Article
Uncontrolled Keywords: Co-amorphous; Solubility; Dissolution; Supersaturation; Drug rich phase; LLPS
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Quality Assurance
Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Library
Date Deposited: 28 Jan 2022 04:39
Last Modified: 28 Jan 2022 04:39
URI: http://eprints.manipal.edu/id/eprint/157837

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