Hypovitaminosis D and Parathyroid Hormone Response in Critically Ill Children with Sepsis: A Case-control Study

*, Ravikiran S R and Bhat, Kamalakshi G and Kamath, Nutan and Manjrekar, Poornima Ajay and Acharya, Sahana Devadasa and Kubsad, Payal (2021) Hypovitaminosis D and Parathyroid Hormone Response in Critically Ill Children with Sepsis: A Case-control Study. Indian Journal of Critical Care Medicine, 25 (8). pp. 924-928. ISSN 09725229

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Abstract

Background: Critically ill Indian children have a higher prevalence of vitamin D deficiency. However, there is not much data available on the subgroup with sepsis. It has been reported that there is an impaired response of parathyroid hormone (PTH) to vitamin D deficiency in critically ill children and adults. Hence, we also sought to analyze the PTH response to vitamin D among the subgroup of critically ill children with sepsis. Patients and methods: Vitamin D and PTH levels of 84 critically ill children with sepsis (cases) and 84 controls were compared between November 2018 and February 2020. Hypovitaminosis D was defined as levels <30 ng/mL. Results: The median (IQR) of vitamin D for cases was 26 (21.30–29.95) ng/mL and that for controls 39.3 (33.65–50.2) ng/mL; p <0.001. Cases had a higher prevalence of hypovitaminosis D as compared to controls (79.7 vs 9.5%; p <0.001). Among the cases, mortality was 24.6% in the 65 children with hypovitaminosis D and 10.5% in those with sufficient vitamin D; the differences were not statistically significant (p = 0.339). There were no significant differences in the duration of pediatric intensive care unit (PICU) stay, serum calcium, PTH, and disease severity among the aforementioned groups. Out of the 65 children with hypovitaminosis D, only 9 (13.8%) were PTH responders. There were no statistically significant differences in mortality, the PICU stay, or disease severity at admission between PTH responders and nonresponders. Conclusions: Hypovitaminosis D was more prevalent among critically ill children with sepsis compared to controls. Parathyroid gland response to hypovitaminosis D was impaired in children with sepsis.

Item Type: Article
Uncontrolled Keywords: alcium, Critically ill children, Parathormone, Vitamin D deficiency
Subjects: Medicine > KMC Mangalore > Paediatrics
Medicine > KMC Mangalore > Pharmacology
Medicine > KMC Mangalore > Biochemistry
Depositing User: KMCMLR User
Date Deposited: 17 Dec 2021 11:02
Last Modified: 17 Dec 2021 11:02
URI: http://eprints.manipal.edu/id/eprint/157867

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