Animal models of chemotherapy‑induced cognitive decline in preclinical drug development

John, Jeena and Kinra, Manas and Mudgal, Jayesh and Nandakumar, K (2021) Animal models of chemotherapy‑induced cognitive decline in preclinical drug development. Psychopharmacology, 238. pp. 3025-3053. ISSN 0033-3158

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Abstract

Rationale Chemotherapy-induced cognitive impairment (CICI), chemobrain, and chemofog are the common terms for mental dysfunction in a cancer patient/survivor under the infuence of chemotherapeutics. CICI is manifested as short/long term memory problems and delayed mental processing, which interferes with a person’s day-to-day activities. Understanding CICI mechanisms help in developing therapeutic interventions that may alleviate the disease condition. Animal models facilitate critical evaluation to elucidate the underlying mechanisms and form an integral part of verifying diferent treatment hypotheses and strategies.Objectives A methodical evaluation of scientifc literature is required to understand cognitive changes associated with the use of chemotherapeutic agents in diferent preclinical studies.This review mainly emphasizes animal models developed with various chemotherapeutic agents individually and in combination, with their proposed mechanisms contributing to the cognitive dysfunction. This review also points toward the analysis of chemobrain in healthy animals to understand the mechanism of interventions in absence of tumor and in tumor-bearing animals to mimic human cancer conditions to screen potential drug candidates against chemobrain.Results Substantial memory defcit as a result of commonly used chemotherapeutic agents was evidenced in healthy and tumor- bearing animals. Spatial and episodic cognitive impairments, alterations in neurotrophins, oxidative and infammatory markers, and changes in long-term potentiation were commonly observed changes in diferent animal models irrespective of the chemotherapeutic agent.Conclusion Dyscognition exists as one of the serious side efects of cancer chemotherapy. Due to difering mechanisms of chemotherapeutic agents with difering tendencies to alter behavioral and biochemical parameters, chemotherapy may present a signifcant risk in resulting memory impairments in healthy as well as tumor- bearing animals

Item Type: Article
Uncontrolled Keywords: Animal models; Chemobrain; Chemotherapeutic agents; Cognitive impairment
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 28 Jan 2022 04:21
Last Modified: 28 Jan 2022 04:21
URI: http://eprints.manipal.edu/id/eprint/158054

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