Synthesis, Molecular Docking and Evaluation of Library of 3-Mercapto-1,2,4-Triazole Derivatives as Antimicrobial Agents

Nayak, Swarnagowri and Gaonkar, Santosh L and Hakkimane, Sushruta S. and Swapna, B and Shetty, Nithin kumar (2021) Synthesis, Molecular Docking and Evaluation of Library of 3-Mercapto-1,2,4-Triazole Derivatives as Antimicrobial Agents. Asian Journal of Chemistry, 33 (12). pp. 3039-3046. ISSN 0970-7077

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Abstract

Due to the increasing microbial resistance to antibacterial and antifungal drugs, the development of new antimicrobial agents is an urgent priority. In search of newer antimicrobial agents, a series of 4,5-disubstituted-3-mercapto-1,2,4-triazole derivatives were synthesized from aromatic acids and substituted isothiocyanates. The in silico study was performed to study the binding interactions of the synthesized compounds with the active pocket of CYP51. Among the synthesized 3-mercapto-triazole derivatives, compounds 6r, 6s and 6u exhibited promising antimicrobial activity comparable to standard drugs. The results suggested that the structural modification to 3-mercapto�1,2,4-triazole derivatives could lead to promising antimicrobial scaffolds

Item Type: Article
Uncontrolled Keywords: 3-Mercapto-1,2,4-triazoles, Intramolecular cyclization, Molecular docking, Antibacterial activity, Antifungal activity
Subjects: Engineering > MIT Manipal > Biotechnology
Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 20 Jan 2022 09:08
Last Modified: 20 Jan 2022 09:08
URI: http://eprints.manipal.edu/id/eprint/158125

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