Sharma, Anu Radha and Patagi, Sourav and Abdul Razak, UK and Shetty, Ranjan and Shashikiran, U and Kapaettu, Satyamoorthy and Rai, Padmalatha S (2021) MirSNPs in clopidogrel metabolism genes predict cardiovascular disease risk: a case–control study and metaanalysis. Pharmacogenomics, 22 (2). pp. 99-113. ISSN 1462-2416

PDF 11452 DisplayPdf.pdf - Published Version Restricted to Registered users only Download (736kB) | Request a copy

Abstract

Aim: The present study was conducted to decipher the inter-relationship of SNPs and miRNAs involved in pharmacogenomics of clopidogrel on predisposition to cardiovascular diseases (CVDs). Materials & methods: A case–control study was conducted on 410 cases and 386 controls to analyze the association of 13 mirSNPs on CVDs risk. Genotyping was performed by tetra- rimer amplification refractory mutation system PCR and validated using Sanger DNA sequencing. miRNA expression analysis was performed using TaqMan assays. A meta-analysis was performed for PON1 rs662 with coronary artery disease. Results & conclusion: PON1 rs662, PON1 rs3917577, CYP3A5 rs15524, COL4A1 rs874204 and PTGIR rs1126510 polymorphisms showed association with CVDs. The miRNA hsa-miR-224-5p showed differential expression in the PON1 rs3917577 GG genotype.The meta-analysis showed the population-specific impact of PON1 rs662 on South Asian and Middle East populations

Actions (login required)

View Item