Emerging role of cellular senescence in the pathogenesis of oral submucous fibrosis and its malignant transformation

Radhakrishnan, Raghu (2021) Emerging role of cellular senescence in the pathogenesis of oral submucous fibrosis and its malignant transformation. Head & Neck, 43 (10). pp. 3153-3164. ISSN 1043-3074

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Abstract

Senescence is a common denominator in wound healing, fibrosis, and cancer. Although, senescence is transiently ntifibrotic, when prolonged, promotes fibrosis and alignant transformation. Eligible studies indexed in MEDLINE, Embase and Web of Science were searched to understand the role of cellular senescence in the pathogenesis of oral submucous fibrosis (OSF) and its malignant transformation. The senescence-associated secretory phenotype (SASP) components like IL-1, IL-6, and GRO-α induce double-strand DNA breaks in keratinocytes and drive genetic instability. SASP derived from myofibroblasts induces epithelial-mesenchymal transition in OSF and facilitates cancer progression. The use of senolytics has been shown to eliminate senescent cells from the areas of fibrosis, thereby preventing malignancy. Naturally occurring agents such as apigenin and kaempferol inhibit SASP. Mechanistic insight into the emerging role of senescence in the pathogenesis of OSF and modalities to inhibit senescence-associated antiapoptotic pathways as a supplementary therapy to prevent malignant transformation of OSF is underlined

Item Type: Article
Uncontrolled Keywords: Cellular senescence; myofibroblasts; oral cancer; oral submucous fibrosis; senescence-associated secretory phenotype
Subjects: Dentistry > MCODS Manipal > Oral Pathology and Microbiology
Depositing User: KMC Library
Date Deposited: 28 Jan 2022 03:50
Last Modified: 28 Jan 2022 03:50
URI: http://eprints.manipal.edu/id/eprint/158151

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