Effect of Mucuna pruriens (Linn.) on Global Cerebral Ischemia-induced Motor Incoordination

Nayak, Vanishri S and Pai, KSR and Nayak, Sunil S and Kumar, Nitesh (2021) Effect of Mucuna pruriens (Linn.) on Global Cerebral Ischemia-induced Motor Incoordination. Tropical Journal of Pharmaceutical Research, 20 (6). pp. 1193-1198. ISSN 1596-9827

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Purpose: To evaluate the effect of Mucuna pruriens on ischemia-induced motor incoordination.Methods: Male Wistar rats were used in this study were divided into eight groups of six rats each. The bilateral common carotid artery (BCA) was occluded to induce global cerebral ischemia.Carboxymethylcellulose (CMC) was used as a vehicle for this while quercetin was used as the standard.The rats were fed with the methanol plant extract of Mucuna pruriens (MP) seeds for ten days. The treatment groups include treatment plus BCA occlusion. Various behavioral parameters such as locomotor activity, motor coordination, spatial learning, and cerebral infarction area were evaluated.Results: A decline in locomotor activity, motor coordination, and spatial learning was observed in the ischemia-induced Wistar rats. The group treated with Mucuna pruriens showed significant protection against brain damage when compared with negative control group.Conclusion: Mucuna pruriens provides effective neuroprotective activity in BCA occlusion-induced cerebral ischemia in rats, and thus a potential therapeutic agent for the clinical management of cerebral ischemia

Item Type: Article
Uncontrolled Keywords: Global ischemia; Mucuna pruriens; Oxidative stress; Brain damage; Locomotor activity; Motor coordination
Subjects: Medicine > KMC Manipal > Anatomy
Dentistry > MCODS Manipal > Oral and Maxillofacial Surgery
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 24 Jan 2022 10:06
Last Modified: 24 Jan 2022 10:06
URI: http://eprints.manipal.edu/id/eprint/158161

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