Remdesivir therapy in patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials

Reddy, Charan Thej Vegivinti and Saravu, Kavitha and Gupta, Nitin Remdesivir therapy in patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials. Annals of Medicine and Surgery, 62. pp. 43-48. ISSN 2049-0801

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Abstract

Purpose: To perform a systematic review and meta-analysis of randomized controlled trials that examined remdesivir treatment for COVID-19.Materials and methods: A systematic literature search was performed using Pubmed, Embase, and ClinicalTrials.gov to identify studies published up to October 25, 2020 that examined COVID-19 treatment with remdesivir. A total of 3 randomized controlled trials that consisted of 1691 patients were included in the meta-analysis.Results: The odds for mechanical ventilation (MV) or extracorporeal membrane oxygenation (ECMO) following treatment was significantly lower in the remdesivir group compared to the control group (OR = 0.48 [95% CI:0.34; 0.69], p < 0.001). The odds of early (at day 14/15; OR = 1.42 [95% CI: 1.16; 1.74], p < 0.001) and late (at day 28/29; OR = 1.44 [95% CI: 1.16; 1.79], p = 0.001) hospital discharge were significantly higher in the remdesivir group compared to the control group. There was no difference in the odds for mortality in patients treated with remdesivir (OR = 0.77 [95% CI: 0.56; 1.06], p = 0.108).Conclusions: Remdesivir attenuates disease progression, leading to lower odds of MV/ECMO and greater odds of hospital discharge for COVID-19 patients. However, remdesivir does not affect odds of mortality

Item Type: Article
Uncontrolled Keywords: Coronavirus; SARS virus; Antiviral agents; Therapeutic uses
Subjects: Medicine > KMC Manipal > Medicine
Depositing User: KMC Library
Date Deposited: 26 Jan 2022 08:53
Last Modified: 26 Jan 2022 08:53
URI: http://eprints.manipal.edu/id/eprint/158193

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