Neurodegenerative Pathways in Alzheimer’s Disease: A Review

Kunnath, Anu Ramachandran and Das, Subham and Joseph, Alex and Shenoy, Gautham G and Alex, Angel Treasa and Mudgal, Jayesh (2021) Neurodegenerative Pathways in Alzheimer’s Disease: A Review. Current Neuropharmacology, 19. pp. 679-692. ISSN 1570-159X

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Abstract

Alzheimer’s disease (AD) is a complex neurodegenerative disease that leads to insidious deterioration of brain functions and is considered the sixth leading cause of death in the world.Alzheimer’s patients suffer from memory loss, cognitive deficit and behavioral changes; thus, they eventually follow a low-quality life. AD is considered as a multifactorial disorder involving different neuropathological mechanisms. Recent research has identified more than 20 pathological factors that are promoting disease progression. Three significant hypotheses are said to be the root cause of disease pathology, which include acetylcholine deficit, the formation of amyloid-beta senile plaques and tau protein hyperphosphorylation. Apart from these crucial factors, pathological factors such as apolipoprotein E (APOE), glycogen synthase kinase 3β, notch signaling pathway,Wnt signaling pathway, etc., are considered to play a role in the advancement of AD and therefore could be used as targets for drug discovery and development. As of today, there is no complete cure or effective disease altering therapies for AD. The current therapy is assuring only symptomatic relief from the disease, and progressive loss of efficacy for these symptomatic treatments warrants the discovery of newer drugs by exploring these novel drug targets. A comprehensive understanding of these therapeutic targets and their neuropathological role in AD is necessary to identify novel molecules for the treatment of AD rationally

Item Type: Article
Uncontrolled Keywords: Alzheimer’s disease; Neurodegenerative pathways; Novel drug targets; Acetylcholinesterase; Glycogen synthase kinase; Notch signaling; Apolipoprotein E
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Biotechnology
Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 26 Jan 2022 10:23
Last Modified: 26 Jan 2022 10:23
URI: http://eprints.manipal.edu/id/eprint/158198

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