Hot-melt extrusion technique: A novel continuous manufacturing method for enteric-coated pellets

Roychowdhury, Rajeshwari and Kara, Divya Dhatri and Rathnanand, Mahalaxmi (2021) Hot-melt extrusion technique: A novel continuous manufacturing method for enteric-coated pellets. Journal of Applied Pharmaceutical Science, 11 (7). pp. 13-19. ISSN 2231-3354

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Abstract

The technology of hot-melt extrusion (HME) is becoming a progressively appealing way to develop different drug delivery systems. A wide range of pharmaceutical dosage forms and formulations from oral to topical and parenteral can be prepared. The dosage forms formulated using HME technique are composite mixtures of active pharmaceutical agents, active excipients, and other processing aids. HME has many advantages over traditional techniques of pharmaceutical development, such as non-solvent technology, lower processing requirements, uninterrupted activity,and greater possibility of uniform suspension and increased bioavailability. This paper addresses enteric-coated pellet pharmaceutical applications and its process techniques using the HME technology and its applications in pharmaceutical industries for an efficient pathway for a novel drug delivery system

Item Type: Article
Uncontrolled Keywords: Hot-melt extrusion (HME); Enteric-coated pellets; Pelletization; Twin screw; Extruder; Novel drug delivery; System (NDDS)
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Library
Date Deposited: 01 Feb 2022 08:54
Last Modified: 01 Feb 2022 08:54
URI: http://eprints.manipal.edu/id/eprint/158219

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