3D Atom based QSAR model of DprE1 inhibitors as AntitubercularAgents

Poojita, K and Fathima, Fajeelath and Ray, Rajdeep and Kumar, Lalit and Verma, Ruchi (2021) 3D Atom based QSAR model of DprE1 inhibitors as AntitubercularAgents. Research Journal of Pharmacy and Technology, 14 (11). pp. 5903-5910. ISSN 09743618

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Abstract

Tuberculosis disease is world’s biggest threat to health with a high mortality rate. There has been a steady surge in the frequency of MDR-TB and XDR-TB. Hence, it is imperative to encourage the research and development of novel drugs to counteract the infection. Decaprenylphosphoryl-ß-D-ribose-2'α-epimerase 1 (DprE1) is a valuable enzyme which is responsible for the stability and virulence of the infection causing bacteria (Mycobacterium tuberculosis) thereby making it a perfect target for drugs anti TB activity. This study represent atom based 3D QSAR model consisting the derivatives of DprE1 inhibitors and provides guidance and insight to develop and identify new novel molecule which have good therapeutic efficiency as Anti TB drugs

Item Type: Article
Uncontrolled Keywords: DprE1; Mycolic acid; Mycobacterium tuberculosis; Atom based 3D QSAR; MDR-TB
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Library
Date Deposited: 01 Feb 2022 08:55
Last Modified: 01 Feb 2022 08:55
URI: http://eprints.manipal.edu/id/eprint/158230

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