Poojita, K and Fathima, Fajeelath and Ray, Rajdeep and Kumar, Lalit and Verma, Ruchi (2021) 3D Atom based QSAR model of DprE1 inhibitors as AntitubercularAgents. Research Journal of Pharmacy and Technology, 14 (11). pp. 5903-5910. ISSN 09743618

PDF 14002 DisplayPdf.pdf - Published Version Restricted to Registered users only Download (588kB) | Request a copy

Abstract

Tuberculosis disease is world’s biggest threat to health with a high mortality rate. There has been a steady surge in the frequency of MDR-TB and XDR-TB. Hence, it is imperative to encourage the research and development of novel drugs to counteract the infection. Decaprenylphosphoryl-ß-D-ribose-2'α-epimerase 1 (DprE1) is a valuable enzyme which is responsible for the stability and virulence of the infection causing bacteria (Mycobacterium tuberculosis) thereby making it a perfect target for drugs anti TB activity. This study represent atom based 3D QSAR model consisting the derivatives of DprE1 inhibitors and provides guidance and insight to develop and identify new novel molecule which have good therapeutic efficiency as Anti TB drugs

Actions (login required)

View Item