Role of Statins in New-onset Diabetes Mellitus: The Underlying Cause,Mechanisms Involved, and Strategies to Combat

Keni, Raghuvir and Sekhar, Abinitha and Gourishetti, Karthik and Nayak, Pawan Ganesh and Kinra, Manas and Kumar, Nitesh and Shenoy, Rekha R and Kishore, Anoop and Nandakumar, Krishnadas (2021) Role of Statins in New-onset Diabetes Mellitus: The Underlying Cause,Mechanisms Involved, and Strategies to Combat. Current Drug Targets, 22. pp. 1-8. ISSN 1389-4501

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Abstract

Statins have transformed the treatment of cardiovascular diseases through primary and secondary prevention of events. Despite the success of statin's management of cardiovascular conditions, certain clinical trials, reviews, and meta-analysis point out that statins have the propensity to induce diabetes. The risk further increases with intensive statin therapy or in patients with diabetes.A proper mechanism for the induction of the diabetic condition has not yet been determined. The involvement of statin with beta cells in insulin secretion and peripheral cells in insulin resistance has been widely studied and established. The present review provides an update on the recent understanding of statin-induced diabetes. This covers the origin of statins, their development, possible mechanisms that explain the adverse effects in glucose homeostasis, and probable targets to remedy the condition

Item Type: Article
Uncontrolled Keywords: Statins; Diabetes; Metabolic syndrome; Hypercholesterolemia; Drug-induced diabetes; Cholesterol
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 01 Feb 2022 10:49
Last Modified: 01 Feb 2022 10:49
URI: http://eprints.manipal.edu/id/eprint/158248

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