Prognostic significance of CD30 expression in diffuse large B-cell lymphoma: A systematic review with meta-analysis

Radhakrishnan, Raghu A (2021) Prognostic significance of CD30 expression in diffuse large B-cell lymphoma: A systematic review with meta-analysis. journal of oral pathology & medicine, 50 (6). pp. 587-593. ISSN 09042512

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Abstract

Background CD30 is variably expressed in diffuse large B-cell lymphoma (DLBCL), but its prognostic potential for the ected patients remains debatable and unclear. Therefore, we aimed to determine the frequency of CD30 expression in DLBCL and its potential for prognostic determination. Methods An electronic systematic review was performed using ultiple databases, followed by a quantitative meta- nalysis to assess the frequency of CD30 expression with positivity cut- ff values of >0% and >20%, and to determine its association with clinicopathological features and patients’ survival. Results Using a cut-off value >0%, we observed that 3.5%–59.1% of the cases were considered positive for CD30. There was a significant association of the protein expression with a lower number of extra-nodal sites affected by the neoplasm, with Ann Arbor advanced stage, the absence of B-symptoms, the lack of MYC and BCL2 translocations, and a lower ECOG performance. Using a cut-off value >20%, we observed that 2.5%–36.7% of the cases were considered positive for CD30, being significantly associated with a lower number of extra-nodal sites affected by the neoplasm, Ann Arbor stages III/IV, non-GCB tumours, the lack of MYC and BCL2 translocations, and a lower ECOG value. CD30 expression was significantly associated with a better survival rate, regardless of what cut-off parameter was used. Conclusion Despite variations in the ut-off values used to determine CD30 positivity in DLBCL, the expression of this protein seems to be associated with a higher survival rate and better prognosis.

Item Type: Article
Uncontrolled Keywords: CD30; brentuximab vedotin; diffuse large B-cell lymphoma; lymphoma; prognosis
Subjects: Dentistry > MCODS Manipal > Oral Pathology and Microbiology
Depositing User: KMC Library
Date Deposited: 07 Feb 2022 04:36
Last Modified: 07 Feb 2022 04:36
URI: http://eprints.manipal.edu/id/eprint/158264

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