Multifunctional lipidic nanocarriers for efective therapy of glioblastoma: recent advances in stimuli‑responsive, receptor and subcellular targeted approaches

Hegde, Manasa Manjunath and Mutalik, Srinivas and Rao, Satish BS (2022) Multifunctional lipidic nanocarriers for efective therapy of glioblastoma: recent advances in stimuli‑responsive, receptor and subcellular targeted approaches. Journal of Pharmaceutical Investigation, 52. pp. 49-74. ISSN 2093-6214

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Abstract

Background Glioblastoma, or glioblastoma multiforme (GBM), remains a fatal cancer type despite the remarkable progress in understanding the genesis and propagation of the tumor. Current treatment modalities, comprising mainly of surgery followed by adjuvant chemoradiation, are insufcient for improving patients' survival owing to existing hurdles, including the blood–brain barrier (BBB). In contemporary practice, the prospect of long-term survival or cure continues to be a challenge for patients sufering from GBM. This review provides an insight into the drug delivery strategies and the signifcant eforts made in lipid-based nanoplatform research to circumvent the challenges in optimal drug delivery in GBM.Area covered Owing to the unique properties of lipid-based nanoplatforms and advancements in clinical translation, this article describes the application of various stimuli-responsive lipid nanocarriers and tumor subcellular organelle-targeted therapy to give an idea about the strategies that can be applied to enhance site- pecifc drug delivery for GBM. Furthermore,active targeting of drugs via surface-modifed lipid-based nanostructures and recent fndings in alternative therapeutic platforms such as gene therapy, immunotherapy, and multimodal therapy have also been overviewed.Expert opinion Lipid-based nanoparticles stand out among the other nanocarriers explored for GBM drug delivery, as they support both passive and active drug targeting by crossing/bypassing the BBB at the same time minimizing toxicity and projects better pharmacological parameters. Although these nanocarriers could be a plausible choice for treating GBM, indepth research is essential to advance neuro-oncology research and enhance outcomes in patients with brain tumors

Item Type: Article
Uncontrolled Keywords: Glioblastoma multiforme; Blood–brain barrier; Lipid-based nanocarriers; Lipid–polymer hybrid nanoparticles; Targeted drug delivery
Subjects: Life Sciences > MLSC Manipal
Pharmacy > MCOPS Manipal > Pharmaceutics
Research > Research Center - Health Sciences
Depositing User: KMC Library
Date Deposited: 24 Feb 2022 10:15
Last Modified: 24 Feb 2022 10:15
URI: http://eprints.manipal.edu/id/eprint/158344

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