Collagen Nanoparticles in Drug Delivery Systems and Tissue Engineering

Arun, Ashni and Malrautu, Pratyusha and Laha, Anindita and Luo, Hongrong and Ramakrishna, Seeram (2021) Collagen Nanoparticles in Drug Delivery Systems and Tissue Engineering. applied sciences, 11 (23). ISSN 2076-3417

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Official URL: https://www.mdpi.com/journal/applsci

Abstract

The versatile natural polymer, collagen, has gained vast attention in biomedicine. Due to its biocompatibility, biodegradability, weak antigenicity, biomimetics and well-known safety profile, it is widely used as a drug, protein and gene carrier, and as a scaffold matrix in tissue engineering. Nanoparticles develop favorable chemical and physical properties such as increased drug half-life, improved hydrophobic drug solubility and controlled and targeted drug release. Their reduced toxicity, controllable characteristics of scaffolds and stimuli-responsive behavior make them suitable in regenerative medicine and tissue engineering. Collagen associates and absorbs nanoparticles leading to significant impacts on their biological functioning in any biofluid. This review will discuss collagen nanoparticle preparation methods and their applications and developments in drug delivery systems and tissue engineering.

Item Type: Article
Uncontrolled Keywords: drug delivery systems (DDS); tissue engineering (TE); polymers; collagen; nanoparticle (NP)
Subjects: Engineering > MIT Manipal > Chemical
Depositing User: MIT Library
Date Deposited: 03 Mar 2022 08:40
Last Modified: 03 Mar 2022 08:40
URI: http://eprints.manipal.edu/id/eprint/158361

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