Current insights and latest updates in sperm motility and associated applications in assisted reproduction

Dcunha, Reyon and Ananda, Hanumappa and Kumari, Sandhya and Adiga, Satish Kumar and Kalthur, Guruprasad (2022) Current insights and latest updates in sperm motility and associated applications in assisted reproduction. Reproductive Sciences, 7 (25). pp. 1-19. ISSN 1933-7191

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Abstract

Spermatozoon is amotile cell with a special ability to travel through the woman’s reproductive tract and fertilize an oocyte. To reach and penetrate the oocyte, spermatozoa should possess progressive motility. Therefore, motility is an important parameter during both natural and assisted conception. The global trend of progressive reduction in the number andmotility of healthy spermatozoa in the ejaculate is associated with increased risk of infertility. Therefore, developing approaches for maintaining or enhancing human sperm motility has been an important area of investigation. In this review we discuss the physiology of sperm, molecular pathways regulating sperm motility, risk factors affecting sperm motility, and the role of sperm motility in fertility outcomes. In addition, we discuss various pharmacological agents and biomolecules that can enhance spermmotility in vitro and in vivo conditions to improve assisted reproductive technology (ART) outcomes. This article opens dialogs to help toxicologists, clinicians, andrologists, and embryologists in understanding the mechanism of factors influencing sperm motility and various management strategies to improve treatment outcomes.

Item Type: Article
Uncontrolled Keywords: Assisted reproductive technology; male infertility; spermmotility; spermmotility enhancers.
Subjects: Medicine > KMC Manipal > Clinical Embryology
Depositing User: KMC Library
Date Deposited: 05 Mar 2022 08:49
Last Modified: 05 Mar 2022 08:49
URI: http://eprints.manipal.edu/id/eprint/158411

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