Factors affecting the outcomes in patients with acute respiratory distress syndrome in a tertiary care setting

Rashid, Muhammed and Ramakrishnan, Manasvini and Muthu, Deepa Sudalai and Viji, PC and Thunga, Girish and Vijayanarayana, K and Shanbhag, Vishal and Acharya, Raviraja and Nair, Sreekumaran N (2022) Factors affecting the outcomes in patients with acute respiratory distress syndrome in a tertiary care setting. Clinical Epidemiology and Global Health, 13. pp. 1-7. ISSN 2213-3984

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Abstract

Purpose: The clinical profile and factors affecting outcomes in acute respiratory distress syndrome (ARDS) from adequately sample-sized Indian studies are still lacking. We aimed to investigate the clinical profile, treatment pattern, outcomes; and to assess factors affecting non-recovery in ARDS patients. Patients and methods: A retrospective observational study was conducted among adult ARDS patients admitted during five year period (January 2014–December 2018) in a South Indian tertiary care setting. The relevant data were collected from the medical records to the data collection form. The univariate and multivariate logistic regression analyses were conducted to identify the predictors of outcomes using SPSS v20. Results: A total of 857 participants including 496 males and 361 females with a mean age of 46.86 ± 15.81 years were included in this study. Fever (70.9%), crepitation (58.3%), breathlessness (56.9%), and cough (45%) were the major clinical presentation. Hypertension (25.2%), kidney disease (23.8%), and diabetes (22.3%) were the major comorbidities; and sepsis (37.6%), pneumonia (33.3%), and septic shock (27.5%) were the major etiological factors observed. Antibiotics and steroids were administered to 97.9% and 52.3% of the population, respectively. The recovery rate was 47.49%. The patients with scrub typhus, dengue, pancreatitis, and oxygen supplementation had significantly lower mortality. The factors such as advanced age, sepsis, septic shock, liver diseases, and ventilation requirements were observed to be the independent predictors of non-recovery in ARDS patients. Conclusion: A comparable recovery rate was observed in our population. Advanced age, sepsis, septic shock, liver diseases, and ventilation requirements were the independent predictors of non-recovery.

Item Type: Article
Uncontrolled Keywords: ARDS; predictors; recovery; sepsis; India.
Subjects: Medicine > KMC Manipal > Critical care
Medicine > KMC Manipal > Medicine
Pharmacy > MCOPS Manipal > Pharmacy Practice
Depositing User: KMC Library
Date Deposited: 25 Mar 2022 06:19
Last Modified: 25 Mar 2022 06:19
URI: http://eprints.manipal.edu/id/eprint/158494

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