Modulation of Gut-Brain Axis by Probiotics: A Promising Anti-depressant Approach

Rajanala, Koumudhi and Kumar, Nitesh and Rao, Mallikarjuna C (2021) Modulation of Gut-Brain Axis by Probiotics: A Promising Anti-depressant Approach. Current Neuropharmacology, 19 (7). pp. 990-1006. ISSN 1570-159X

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Abstract

The human digestive system is embedded with trillions of microbes of various species and genera. These organisms serve several purposes in the human body and exist in symbiosis with the host. Their major role is involved in the digestion and conversion of food materials into many useful substrates for the human body. Apart from this, the gut microbiota also maintains healthy communication with other body parts, including the brain. The connection between gut microbiota and the brain is termed as gut-brain axis (GBA), and these connections are established by neuronal,endocrine and immunological pathways. Thus, they are involved in neurophysiology and neuropathology of several diseases like Parkinson’s disease (PD), Alzheimer’s disease (AD), depression,and autism. There are several food supplements such as prebiotics and probiotics that modulate the composition of gut microbiota. This article provides a review about the role of gut microbiota in depression and supplements such as probiotics that are useful in the treatment of depression

Item Type: Article
Uncontrolled Keywords: Gut microbiota; Gut-brain axis (GBA); Depression; Probiotics; Prebiotics; Food supplement
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 25 Apr 2022 04:27
Last Modified: 25 Apr 2022 04:27
URI: http://eprints.manipal.edu/id/eprint/158549

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