Shenoy, Sangeetha U and Adiga, Divya and Kabekkodu, Shama Prasada and Radhakrishnan, Raghu (2022) Molecular implications of HOX genes targeting multiple signaling pathways in cancer. Cell Biology and Toxicology, 38 (6). pp. 1-30. ISSN 0742-2091

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Abstract

Homeobox (HOX) genes encode highly conserved homeotic transcription factors that play a crucial role in organogenesis and tissue homeostasis.Their deregulation impacts the function of several regulatory molecules contributing to tumor initiation and progression. A functional bridge exists between altered gene expression of individual HOX genes and tumorigenesis. This review focuses on how deregulation in the HOX-associated signaling pathways contributes to the metastatic progression in cancer. We discuss their functional signifcance, clinical implications and ascertain their role as a diagnostic and prognostic biomarker in the various cancer types.Besides, the mechanism of understanding the theoretical underpinning that afects HOX-mediated therapy resistance in cancers has been outlined. The knowledge gained shall pave the way for newer insights into the treatment of cancer

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