Hemagglutination Inhibition Antibody Response Following Influenza A(H1N1)pdm09 Virus Natural Infection: A Cross- Sectional Study from Thirthahalli, Karnataka, India

Hari Alladi, Chandana Sai and Jagadesh, Anitha and Prabhu, Suresha G and Arunkumar, G (2019) Hemagglutination Inhibition Antibody Response Following Influenza A(H1N1)pdm09 Virus Natural Infection: A Cross- Sectional Study from Thirthahalli, Karnataka, India. Viral Immunology, 32 (5). pp. 1-4. ISSN 08828245

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Abstract

Influenza viruses are major respiratory pathogens that cause seasonal epidemics and occasional pandemics. Immune response to influenza viruses is majorly targeted against the hemagglutinin antigen. A laboratory-based retrospective cross-sectional study was conducted on 50 acute and 50 follow-up samples to assess the immune response to influenza A H1N1)pdm09 virus after natural infection and detect the presence of pre-existing antibodies against influenza A(H3N2) and influenza B viruses. Two–fourfold rise in hemagglutinationinhibition (HAI) titer was observed in 100% of the follow-up samples for influenza A(H1N1)pdm09 virus. No change in HAI titers for influenza A(H3N2) and influenza B viruses was observed.

Item Type: Article
Uncontrolled Keywords: influenza virus; hemagglutination-inhibition assay; immune response; pre-existing antibodies
Subjects: Departments at MU > Manipal Centre for Virus Research
Depositing User: KMC Library
Date Deposited: 25 Apr 2022 04:25
Last Modified: 25 Apr 2022 04:25
URI: http://eprints.manipal.edu/id/eprint/158610

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