Effect of Piper betel Leaf Extract in Alzheimer’s Disease

Upadhyaya, Shreeraksha and Gangachannaiah, Shivaprakash and Chandrashekar, Pallavi Lakshmi (2019) Effect of Piper betel Leaf Extract in Alzheimer’s Disease. Biomedical and Pharmacology Journal, 12 (3). pp. 1425-1431. ISSN 09746242

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Alzheimer’s disease is a common neurological disorder affecting a significant proportion of the elderly population.There are only a few drugs which can be used safely to treat it. We sought to investigate for the first time Piper betel leaf, a postmeal mouth freshener for its potential use in Alzheimer’s disease. Five groups of male Wistar rats with six rats in each groupaged 10-12 weekswere used. The control group received the distilledwater, aluminium chloride (AlCl3) group was treated with AlCl3, the standard group was treated with rivastigmine with AlCl3, and the two test groups received piper betel leaf extract (PBE) at doses of 400mg/ kg and 500mg/kg body weight with AlCl3. AlCl3 was administered orally for 42 days in all the treated groups. Memory and learning were evaluated by Morris water maze test and Passive avoidance test.The results of theMorris water maze test showed reduced mean escape latency period in all the groups on trial day three (Pd”0.05) and on trial day four (P d”0.01) compared to AlCl3 group. The retention of spatial memory by probe trial showed that PBE and rivastigmine treated group spent more time in the target (platform) quadrant when compared to AlCl3 group (Pd”0.01). The passive avoidance test showed asignificant increase in step through latency in standard and test groups compared to theAlCl3 treated group.The weight of the rats treated with AlCl3 and PBE was reduced at the end of the treatment period while increased in standard and control group.The study shows the beneficial effects of Piper betel leaves in Alzheimer’s disease by significantly improving the learning and memory functions in rats.

Item Type: Article
Uncontrolled Keywords: Piper betel leaves; Alzheimer’s disease; Learning; Memory
Subjects: Medicine > KMC Manipal > Pharmacology
Medicine > KMC Manipal > Physiology
Depositing User: KMC Library
Date Deposited: 25 Apr 2022 04:25
Last Modified: 25 Apr 2022 04:25
URI: http://eprints.manipal.edu/id/eprint/158622

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