Functionalization of Gold Nanoparticles with Monosaccharide Mannose

Dash, Sambit and Rao, Pragna and Kamath, Ullas and Pai, Aparna R and Reddy, Prasanna Kumar Gayam and Rati, Ekta and Karnik, Shivani and Joseph, Alex and Alex, Angel Treasa (2021) Functionalization of Gold Nanoparticles with Monosaccharide Mannose. Research Journal of Pharmacy and Technology, 14 (12). 6281-6284.. ISSN 0974-360X

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Abstract

Gold nanoparticles have found a wide range of application in biomedical sciences. Unique properties of these metal nanoparticles include surface plasmon resonance and size dependent colour change. Various molecules have been functionalized on the gold nanoparticles surface but carbohydrates have garnered attention due to their properties and their role in living systems. However certain challenges make carbohydrate-gold nanoparticles association difficult to obtain and stabilize. This study was carried out to chemically remodel gold nanoparticles by adding a monosaccharide mannose to its surface. A modified phase transfer method was used to synthesize gold nanoparticles. The surface of the nanoparticles was fixed with cyanuric chloride to serve as a linker. Mannose was then linked to the linker molecule. All three stages of the process, gold nanoparticles, and gold nanoparticles with linker and gold nanoparticles with the carbohydrate were analyzed for size and stability. Zeta potential and UV-vis data exhibited stable gold nanoparticles dispersion, successful binding of linker molecule as well as the carbohydrate. This study shows a simple, cost-effective and robust method of glycomodification of gold nanoparticles surface which can further find use in wide ranging applications

Item Type: Article
Uncontrolled Keywords: Gold Nanoparticles; Functionalization; Mannose; Cyanuric Chloride; Zeta Potential
Subjects: Medicine > MMMC Manipal > Biochemistry
Medicine > KMC Manipal > Neurology
Pharmacy > MCOPS Manipal > Pharmaceutical Biotechnology
Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Depositing User: KMC Library
Date Deposited: 25 Apr 2022 04:24
Last Modified: 25 Apr 2022 04:24
URI: http://eprints.manipal.edu/id/eprint/158636

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