The Role of Calcium Signaling in Regulation of Epithelial-Mesenchymal Transition

Adiga, Divya and Radhakrishnan, Raghu A and Chakrabarty, Sanjiban and Kabekkodu, Shama Prasada (2022) The Role of Calcium Signaling in Regulation of Epithelial-Mesenchymal Transition. Cells Tissues Organs, 211 (2). pp. 134-156.

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Despite substantial advances in the field of cancer therapeutics, metastasis is a significant challenge for a favorable clinical outcome. Epithelial to mesenchymal transition (EMT) is a process of acquiring increased motility, invasiveness, and therapeutic resistance by cancer cells for their sustained growth and survival. A plethora of intrinsic mechanisms and extrinsic microenvironmental factors drive the process of cancer metastasis. Calcium (Ca2+) signaling plays a critical role in dictating the adaptive metastatic cell behavior comprising of cell migration, invasion, angiogenesis, and intravasation. By modulating EMT, Ca2+ signaling can regulate the complexity and dynamics of events leading to metastasis. This review summarizes the role of Ca2+ signal remodeling in the regulation of EMT and metastasis in cancer

Item Type: Article
Uncontrolled Keywords: Epithelial to mesenchymal transition (EMT); Calcium signal remodeling; Calcium channels; Calcium pumps; Metastasis; Cancer
Subjects: Dentistry > MCODS Manipal > Oral Pathology and Microbiology
Life Sciences > MLSC Manipal
Depositing User: KMC Library
Date Deposited: 09 May 2022 06:31
Last Modified: 09 May 2022 06:31

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