Objective Diagnosis of Cervical Cancer by Tissue Protein Profile Analysis

Patil, Ajeetkumar and Bhat, Sujatha and Rai, Lavanya and Kartha, VB and Chidangil, Santhosh (2011) Objective Diagnosis of Cervical Cancer by Tissue Protein Profile Analysis. AIP Conf.Proc. pp. 226-227.

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Abstract

Protein profiles of homogenized normal cervical tissue samples from hysterectomy subjects and cancerous cervical tissues from biopsy samples collected from patients with different stages of cervical cancer were recorded using High Performance Liquid Chromatography coupled with Laser Induced Fluorescence (HPLC-LIF). The Protein profiles were subjected to Principle Component Analysis to derive statistically significant parameters. Diagnosis of sample types were carried out by matching three parameters – scores of factors, squared residuals, and Mahalanobis Distance. ROC and Youden’s Index curves for calibration standards were used for objective estimation of the optimum threshold for decision making and performance.

Item Type: Article
Uncontrolled Keywords: Cancer, Fluorescence, Chromatography
Subjects: Departments at MU > Atomic Molecular Physics
Health Sciences > KMCIC
Medicine > KMC Manipal > Obstetrics & Gynaecology
Depositing User: KMC Manipal
Date Deposited: 24 Oct 2011 09:40
Last Modified: 24 Oct 2011 09:40
URI: http://eprints.manipal.edu/id/eprint/1587

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