Serum adenosine deaminase and C-reactive protein in diabetic patients with and without neuropathy

Khan, Mansoor and Anju, M and Velladath, Saleena Ummer and Hande, Manjunath H (2021) Serum adenosine deaminase and C-reactive protein in diabetic patients with and without neuropathy. Clinical Diabetology, 10 (2). pp. 1-5. ISSN 2450-7458

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Abstract

Background. Diabetic Peripheral Neuropathy (DPN) is one major microvascular complication of long-standing diabetes mellitus with a prevalence of 50–60%. DPN leads to decreased quality of life, increased morbidity, and mortality. C reactive protein (CRP) and adenosine deaminase (ADA) are independent inflammatory markers; the current study aims to evaluate and compare serum ADA, CRP in diabetic patients with and without neuropathy. Methods. A prospective study was done on 160 diabetic patients with and without neuropathy who visited the Medicine Department of Kasturba Hospital Manipal. Patients were grouped into two: diabetics with neuropathy (n = 80) and without neuropathy (n = 80). Serum samples were collected and analyzed for CRP and ADA. Results. The data were analyzed using the independent t-test and Mann-Whitney U test. There was a significantly high level of ADA (P = 0.032) in neuropathy patients when compared with the non-DPN group. No significant difference was seen in CRP levels (P = 0.123) in DPN patients compared to non-DPN patients. Conclusion. Monitoring of inflammatory markers like ADA in diabetic patients can provide insight into preventing DPN and its associated complications.

Item Type: Article
Uncontrolled Keywords: Diabetes mellitus; diabetic peripheral neuropathy; C-reactive protein; adenosine deaminase.
Subjects: Allied Health > MCOAHS Manipal > Medical Laboratory Tech
Medicine > KMC Manipal > Medicine
Depositing User: KMC Library
Date Deposited: 06 Jun 2022 12:25
Last Modified: 06 Jun 2022 12:25
URI: http://eprints.manipal.edu/id/eprint/158791

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