Microparticles in diabetic kidney disease

Sushma, TK and Muttickal, Shilna Swaminathan and Basthi, Pooja Mohan and Nagaraju, Shankar Prasad and Bhojaraja, Mohan V and Sindhura Lakshmi, KL (2022) Microparticles in diabetic kidney disease. Clinica Chimica Acta, 531. pp. 418-425. ISSN 0009-8981

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Abstract

Diabetic kidney disease (DKD) is the most common cause of renal failure and a major contributor to the socioeconomic burden in chronic kidney disease (CKD) patients worldwide. The pathogenesis of DKD involves all the structures in the nephron, and it is indicated by proteinuria, hypertension, and progressive decline in renal function, leading to substantial morbidity and mortality. Due to the limitations of currently available standard markers (albuminuria and glomerular filtration rate) in the diagnosis and clinical grading of DKD, it’s time to have novel biomarkers for early detection, targeted and effective therapy to prevent the progression. Microparticles (MPs) are extracellular vesicles measuring 0.1–1 µm derived by cytoskeletal reorganization in the form of cytoplasmic blebs which alters the phospholipid cytochemistry of the cell membrane. They are shed during cell activation and apoptosis as well as plays an important role in cell-to-cell communication. Over the last few decades, both plasma and urinary MPs have been investigated, validated and the preliminary research looks promising. With alterations in their number and composition documented in clinical situations involving both Type1 and 2 diabetes mellitus, microparticles assay appears to be promising in early diagnosis and prognostication of DKD

Item Type: Article
Uncontrolled Keywords: Chronic kidney disease; Glomerular filtration rate; Diabetic Kidney disease; Microparticles; Proteinuria
Subjects: Medicine > KMC Manipal > Anaesthesiology
Medicine > KMC Manipal > Gastroenterology and Hepatology
Medicine > KMC Manipal > Nephrology
Medicine > KMC Manipal > Pathology
Depositing User: KMC Library
Date Deposited: 06 Jun 2022 13:37
Last Modified: 06 Jun 2022 13:37
URI: http://eprints.manipal.edu/id/eprint/158796

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