Maity, Swastika and Kinra, Manas and Nampoothiri, Madhavan and Arora, Devinder and Pai, Sreedhara Ranganath K and Mudgal, Jayesh (2022) Cafeic acid, a dietary polyphenol, as a promising candidate for combination therapy. Chemical Papers, 76. pp. 1271-1283. ISSN 0366-6352

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Abstract

Increased efectiveness and decreasing toxicity are prime objectives in drug research. Overwhelming evidence suggests the use of appropriate combination therapy for the better efcacy of drugs owing to their synergistic profle. Dietary active constituents play a major role in health outcomes. Therefore, it is possible to increase the efectiveness of the drug by combining contemporary medication with active natural/semi-synthetic constituents. One such dietary constituent, cafeic acid (CA),is a by-product of the shikimate pathway in plants and is a polyphenol of hydroxycinnamic acid class.Extensive research on CA has proposed its efcacy against infammatory, neurodegenerative, oncologic, and metabolic disorders.The synergistic/additive efects of CA in combination with drugs like cafeine, metformin, pioglitazone, and quercetin have been reported in several experimental models and thus the present review is an attempt to consolidate outcomes of this research. Multitarget-based mechanistic studies will facilitate the development of efective combination regimens of CA

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