Metamorphosis of Twin Screw Extruder‑Based Granulation Technology:Applications Focusing on Its Impact on Conventional Granulation Technology

Rao, Rajat Radhakrishna and Pandey, Abhijeet and Hegde, Aswathi R and Mutalik, Srinivas (2022) Metamorphosis of Twin Screw Extruder‑Based Granulation Technology:Applications Focusing on Its Impact on Conventional Granulation Technology. AAPS PharmSciTech, 23. pp. 1-23. ISSN 1530-9932

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Abstract

In order to be at pace with the market requirements of solid dosage forms and regulatory standards, a transformation towards systematic processing using continuous manufacturing (CM) and automated model-based control is being thought through for its fundamental advantages over conventional batch manufacturing. CM eliminates the key gaps through the integration of various processes while preserving quality attributes via the use of process analytical technology (PAT). The twin screw extruder (TSE) is one such equipment adopted by the pharmaceutical industry as a substitute for the traditional batch granulation process. Various types of granulation techniques using twin screw extrusion technology have been explored in the article. Furthermore, individual components of a TSE and their conjugation with PAT tools and the advancements and applications in the feld of nutraceuticals and nanotechnology have also been discussed.Thus, the future of granulation lies on the shoulders of continuous TSE, where it can be coupled with computational mathematical studies to mitigate its complications

Item Type: Article
Uncontrolled Keywords: Continuous manufacturing; Twin screw granulation; Extruder design; Hot melt extruder; Twin screw extrusion; Process analytical techniques
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Library
Date Deposited: 18 Jul 2022 03:54
Last Modified: 18 Jul 2022 03:54
URI: http://eprints.manipal.edu/id/eprint/158827

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