Chloramine-T (N-chloro-p-toluenesulfonamide sodium salt), a versatile reagent in organic synthesis and analytical chemistry: An up to date review

Nayak, Yogeesh N and Gaonkar, Santosh L and Salehuddin, Ebraheem Abdu Musad and Dawsari, Abdullah Mohammed A.L and Harshitha, . and Husain, K and Hassan, Ismail (2022) Chloramine-T (N-chloro-p-toluenesulfonamide sodium salt), a versatile reagent in organic synthesis and analytical chemistry: An up to date review. Journal of Saudi Chemical Society. ISSN 1319-6103

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Abstract

Chloramine-T (CAT), the sodium salt of N-chloro-p-toluenesulfonamide, is a low-cost mild oxidizing agent with a wide range of uses. Most importantly, it can be used in acidic, neutral, and basic conditions. As a result, it’s been widely used in chemistry, particularly in organic synthesis and analytical chemistry. Chloramine-T acts as a source of halonium cation and nitrogen anion and thus acts as base and nucleophile. It reacts with a wide range of functional groups and carries dif�ferent molecular transformations. This paper thoroughly summarises and highlights the synthetic and analytical effectiveness of CAT. This study focuses on current developments as well as some older techniques in which CAT has been employed as an oxidizing agent. This review article stretches a comprehensive profile of the CAT reagent in organic synthesis and analytical chemistry, which will be very useful for further research exploration in this field.

Item Type: Article
Uncontrolled Keywords: Chloramine-T; Oxidant; Cycloaddition; Aziridination; Halogenation; Heterocycle synthesis
Subjects: Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 12 Jul 2022 04:57
Last Modified: 12 Jul 2022 04:57
URI: http://eprints.manipal.edu/id/eprint/158924

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