Enhancing the oral bioavailability of asenapine maleate with bio-enhancer: An in-silico assisted in-vivo pharmacokinetic study

Suresh, Akhil and Narayan, Reema and Tummala, Hari Prabhath and Matcha, Saikumar and Surulivelrajan, Mallayasamy and Nayak, Yogendra and Jagadish, PC and Nayak, Usha Y (2022) Enhancing the oral bioavailability of asenapine maleate with bio-enhancer: An in-silico assisted in-vivo pharmacokinetic study. Journal of Drug Delivery Science and Technology, 70. pp. 1-12. ISSN 1773-2247

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Abstract

The present work is aimed to address the oral bioavailability issue of asenapine maleate with the help of bioenhancers. Molecular modeling platform by Maestro, Schr¨odinger was used to screen a list of bio-enhancer molecules. The bio-enhancer with the highest docking score and the best intermolecular interactions was selected for in-vivo pharmacokinetics studies. Of all the bio-enhancer molecules, quercetin showed the highest docking score (

Item Type: Article
Uncontrolled Keywords: Asenapine maleate; schizophrenia; bioavailability; molecular docking; quercetin.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmaceutics
Pharmacy > MCOPS Manipal > Pharmacology
Pharmacy > MCOPS Manipal > Pharmacy Practice
Depositing User: KMC Library
Date Deposited: 18 Jul 2022 03:57
Last Modified: 18 Jul 2022 03:57
URI: http://eprints.manipal.edu/id/eprint/158926

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