Development of cream to enhance the antifungal activity and reduce the side effects of fluconazole for the treatment of Candida albicans

Bhaskaran, Navya Ajitkumar and Salwa, * and Fernandes, Amanda Velinna and Pydi, Chinna Raja and Kumar, Lalit and Verma, Ruchi and Marques, Shirleen Miriam (2022) Development of cream to enhance the antifungal activity and reduce the side effects of fluconazole for the treatment of Candida albicans. Tenside Surfactants Detergents, 59 (3). pp. 231-239. ISSN 0932-3414

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Abstract

The aim of the present study was to formulate a fluconazole cream for the treatment of Candida albicans. The optimized cream formulationwas prepared using stearic acid, oleic acid, beeswax and borax. The uniform distribution of the active ingredient fluconazole could be confirmed in all formulated creams. The FC-C-C formulation showed satisfactory spreadability and extrudability. FC-C-C delivered (95.07±15.85)% in only 36 h, and the formulation released the drug by an anomalous diffusion mechanism. The viscosity of FC-C-Cwas found to be (63.20 ± 0.83) cP. The antifungal study and animal studies confirmed that the prepared formulation is non-irritant and has an enhanced antifungal activity that reduces the side effects of fluconazole. The studies confirm that the prepared formulationmay be useful for the treatment of Candida albicans.

Item Type: Article
Uncontrolled Keywords: Beeswax; borax; enhanced antifungal activity; enhanced hair growth; fluconazole; stearic acid.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Library
Date Deposited: 25 Jul 2022 08:41
Last Modified: 25 Jul 2022 08:41
URI: http://eprints.manipal.edu/id/eprint/159056

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