Resource-appropriate selection of osteosarcoma treatment protocols in low- and middle-income countries

Mailankody, Sharada (2021) Resource-appropriate selection of osteosarcoma treatment protocols in low- and middle-income countries. Pediatric Blood & Cancer, 69 (25). pp. 1-13. ISSN 1545-5009

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Abstract

Osteosarcoma is a rare malignancy; however, it is still the most common primary bone tumor in adolescents and young adults. Chemotherapy improves survival indubitably in osteosarcoma; nevertheless, the concern is the stagnant progress since the last several decades. There are a handful of active agents and unresolved issues, especially in choosing the ideal chemotherapy regimen. The oncology community is in equipoise regarding the position of high-dose methotrexate (HDMTX), mandatory or adjunct. The choice of therapy becomes widely relevant, including in low- and middle-income countries (LMIC),whereHDMTXadministration brings additional complexities. Research into novel non-HDMTX-based protocols adapted to the available resources is pivotal in improving disease outcomes, especially in LMIC. The current review focuses on real-world challenges in decision-making and provides a comprehensive overview of the evolution of treatment protocols in LMIC.

Item Type: Article
Uncontrolled Keywords: Current management strategies; low- and middle-income countries; non-high-dose methotrexate protocols; osteosarcoma; practical considerations.
Subjects: Medicine > KMC Manipal > Medical Oncology
Depositing User: KMC Library
Date Deposited: 25 Jul 2022 08:39
Last Modified: 25 Jul 2022 08:39
URI: http://eprints.manipal.edu/id/eprint/159097

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