Can Serum Glutathione-S-Transferase Levels In Carcinoma Cervix Be a Predictor Of Radiation Response?

Prabhu, Krishnananda and Bhat, Gopalakrishna P and Vasudevan, DM (2005) Can Serum Glutathione-S-Transferase Levels In Carcinoma Cervix Be a Predictor Of Radiation Response? Indian Journal of Clinical Biochemistry, 20 (1). pp. 95-97.

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Abstract

We conducted a pilot study wherein serum Glutathione-S-tr~nsferase levels were measured before and after radiotherapy in carcinoma cervix patients and correlated with response to treatment during a two-year follow-up period. Out of 17 patients who received radiotherapy, 9 showed a significant decrease (p< 0.005) while 8 showed significant increase (p< 0.004) in post radiotherapy glutathione-S-transferase values as compared to pre treatment values respectively. These patients were followed up for two years and we observed that 71% who had significant increase in post radiotherapy values had relapse of cancer within 2 years where as 66% of those who had significant decrease in post radiotherapy values had no evidence of relapse. This shows that alterations in serum Glutathione-Stransferase levels may help us to predict radiation response.

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