Wound healing activity of aqueous extract of Crotalaria verrucosa in Wistar albino rats

Kumari, Meena and Eesha, BR and Amberkar, Mohan Babu V and Babu, Sarath and Rajshekar, * and Kumar, Neelesh (2010) Wound healing activity of aqueous extract of Crotalaria verrucosa in Wistar albino rats. Asian Pacific Journal of Tropical Medicine. pp. 783-787.

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Abstract

Objective: To evaluate the wound healing effect of aqueous extract of Crotalaria verrucosa (C.verrucosa) in rats. Methods: Three wound models including incision, excision and dead space wmooudnedlss, wgrearneu ulasteidon i nti stshuise sdtruyd yw.e Tighhet , pbarreaamkeintegr ss tsretundgitehd a wnde rhe ybdrreoaxkyipnrgo lsintree ncgotnht einnt iinnc idseioadn swpoaucned wmouodnedls., Rpeerscuelntst:a gTew oof dwoosuensd o fc othnetr aecxttiroanc ta wndit hp earniodd w oift heopuitt hdeelixaalmizeatthioans oinne esxhcoiswieodn tsiisgsnuiefi cbauntt iitn cwraesa sheisg hine rm weiatnh hdyodsreo x8y0p0r omlign/ek,g toctoaml pparortienign wciotnht etnhte acnodn tdrroyl . wTehigeh dt eoxf agmraenthualastoinone treated group showed a significant (P<0.001) reduction in the wound breaking strength when compared to control group in incision type of wound model. Coadministration of C. verrucosa with dexamethasone significantly (P<0.001) increased the breaking strength compared to the cdoenxtarmacettiohna swoanse stirgenaiftiecda notnlyl y( Pg<r0o.u01p). iInnc reexacseisdi obny wtwoou dnods ems oodf etle,s tt heex trpaecrtc oenn taalgl eth oef dtahyes wexocuenpdt tthhee ldoewxearm deothsea swonheic hsu epxphriebsisteedd wonoluyn odn c 1o2ntthra, c1t6iothn .d Iaty ssi gonf idfircuagn ttlrye a(Ptm<e0n.0t0 a1n) dre idt uaclesdo rthevee trismede required for epithelialization and reversed the epithelialization delaying effect of dexamethasone (P<0.001). Conclusions: C. verrucosa was found to possess significant wound healing property. cTohnist rwacatsi oenv,i dseknitn bbyr edaekcirneags est rinen tghteh ,p earnidod g oraf neupliathtieolnia ltiizsastuioen d, riny cwreeaisgeh ti nc othnete rnatt.e Hofe nwcoeu nCd.

Item Type: Article
Uncontrolled Keywords: Crotalaria verrucosa,Incision wound, Excision wound,Dead space wound, Wound breaking strength.
Subjects: Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 24 Nov 2011 04:32
Last Modified: 27 Oct 2016 09:05
URI: http://eprints.manipal.edu/id/eprint/1713

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