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Comparative effect of Sodium fusidate, Framycetin and Calcium mupirocin on experimentally induced burn wound healing

Bairy, KL and Nayak, Veena and Satish Kumar, MC and Adiga, Sachidananda and Holla, Avinash and Kumar, Pawan and Subramanya, Rajesh C and Chandrashekhar, BR and Chogtu, Bharti (2010) Comparative effect of Sodium fusidate, Framycetin and Calcium mupirocin on experimentally induced burn wound healing. Int J Pharm Sci Bio, 1 (2). pp. 100-102.

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Abstract

Topical antibiotics like sodium fusidate, framycetin and calcium mupirocin are used to treat burn wounds. But whether they influence healing of wounds is not known. Aim: to compare the effect of sodium fusidate, framycetin and calcium mupirocin of Apex Laboratories Chennai, on experimentally induced burn wound healing in male Wistar rats and compare with available market preparation namely, Fucidin cream 2% (ranbaxy), T Bact cream (GSK) & Soframycin cream (Sanofi-aventis). Method: Partial thickness burn wounds was inflicted, on Wistar rats under pentobarbitone anesthesia (30mg/kg/i.p), by pouring hot molten wax at 80◦ C into a metal cylinder of 300 mm2 circular opening placed on shaven back of the rat. Animals with partial thickness burn wounds were divided into 7 groups (n=10). Group 1 did not receive any drug and served as control group. Group 2, 3, 4, 5, 6, 7 received sodium fusidate, framycetin, calcium mupirocin, Fucidin 2% (ranbaxy), T Bact (GSK) and So-framycin (Sanofi-aventis) creams topically respectively twice daily for 21 days or till complete healing whichever was earlier. Results: Sodium fusidate significantly decreased the duration of epithelialization increased wound contraction in comparison to the control group. This was confirmed by histopathology studies. Conclusion: Sodium fusidate possess significant wound heal-ing properties.

Item Type: Article
Uncontrolled Keywords: Wound healing, Sodium fusidate, epithelialization.
Subjects: Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 24 Nov 2011 04:18
Last Modified: 24 Nov 2011 04:18
URI: http://eprints.manipal.edu/id/eprint/1753

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