Effect of Phenytoin Sodium on Reproductive Parameters in Adult Male Wistar Rats

Rao, Yeshwanth and Bairy, Laxminarayana K and Paul, Vijay (2009) Effect of Phenytoin Sodium on Reproductive Parameters in Adult Male Wistar Rats. Kuwait Medical Journal, 41 (1). pp. 43-51.

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Abstract

To assess the effects of phenytoin sodium on rat sperm morphology, sperm count, motility and histopathological changes in testis Design: Experimental study Setting: Kasturba Medical College, Manipal, Karnataka State, India Materials and Methods: Male Wistar rats (13-14 weeks old) were treated with phenytoin sodium and sacrificedattheend of 2nd, 4th, 5th, 7th, 10th and 15th week after the last exposure to phenytoin sodium. Epididymal sperm count, sperm motility, sperm morphology and histopathology of testes were analysed. Results: Sperm count and sperm motility were decreased significantlybyphenytoinsodium.Thepercentageofabnormal sperms increased significantlyinatimedependentmanner. Histopathological study revealed that phenytoin sodium caused sloughing of epithelial cells in the testis. Conclusion: Phenytoin sodium caused reversible change in sperm motility, count, morphology and cytoarchitecture of testes.

Item Type: Article
Uncontrolled Keywords: Histopathology, phenytoin sodium, sperm count, sperm morphology, sperm motility.
Subjects: Medicine > KMC Manipal > Anatomy
Medicine > MMMC Manipal > Pharmacology
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 26 Nov 2011 06:57
Last Modified: 05 Oct 2013 06:23
URI: http://eprints.manipal.edu/id/eprint/1779

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