Effect of Phenytoin Sodium on the Biochemical Parameters of Reproductive Function in Male Albino Wistar Rats

Vijay, P and Yeshwanth, R and Bairy, KL (2009) Effect of Phenytoin Sodium on the Biochemical Parameters of Reproductive Function in Male Albino Wistar Rats. Journal of physiological and Biomedical Sciences. pp. 14-18.

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Abstract

To assess the effects of phenytoin sodium on biochemical markers of testicular function. Male Wistar rats (12 weeks old) were treated with phenytoin and sacrificed at the end of 2nd, 4th, 5th, 7th, 10th and 15th week after the last exposure to phenytoin sodium. The testes were removed, weighed and processed for biochemical analysis. The intratesticular testosterone level was significantly (P<0.001) reduced with 50 mg/kg and 100mg/kg treated rats. The intratesticular lactate dehydrogenase (LDH) level was significantly (P<0.001) increased by phenytoin in a time dependent manner regardless of dose. Phenytoin causes reversible change in testosterone and LDH level.

Item Type: Article
Uncontrolled Keywords: phenytoin sodium, testosterone, lactate dehydrogenase
Subjects: Medicine > MMMC Manipal > Anatomy
Medicine > MMMC Manipal > Pharmacology
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 28 Nov 2011 04:28
Last Modified: 28 Nov 2011 04:28
URI: http://eprints.manipal.edu/id/eprint/1781

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