Effect of topical phenytoin on burn wound healing in rats

Meena, K and Mohan, AV and Sharath, B and Somayaji, SN and Bairy, KL (2011) Effect of topical phenytoin on burn wound healing in rats. Indian Journal of Experimental Biology, 49. pp. 56-59.

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Abstract

To evaluate the effect of phenytoin on burn wounds and to compare the effect of the combination of topical phenytoin preparation in dexamethasone treated burn wounds in rats, partial thickness thermal burn wounds were inflicted upon five groups of six rats each. Group I was assigned as control, Group II received the standard silver sulphadiazine, Group III was given topical phenytoin and Group IV received injection dexamethasone, Group V received the combination of the phenytoin and the dexamethasone. The parameters observed were epithelialization period, percentage of wound contraction and histopathological analysis as indicative of the process of healing. Phenytoin group showed significant improvement in burn wound contraction in comparison to standard silver sulphadiazine group, the combination group of topical phenytoin and dexamethasone also showed significant contraction compared to dexamethasone group. The period of epithelialization also decreased significantly in groups II, III and V. In conclusion, phenytoin promotes burn wound healing as evidenced by decrease in period of epithelialization and faster wound contraction.

Item Type: Article
Uncontrolled Keywords: Epithelialization,Phenytoin,Silver sulphadiazine, Wound contraction.
Subjects: Medicine > MMMC Manipal > Anatomy
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 28 Nov 2011 04:32
Last Modified: 28 Nov 2011 04:32
URI: http://eprints.manipal.edu/id/eprint/1783

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