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Effects of chronic prenatal restraint stress on Anxiety in post weaned male and female wistar rats

Cherian, Saju Binu and Bairy, KL and Rao, Muddanna S and Somayaji, SN and Ramnarayan, K (2010) Effects of chronic prenatal restraint stress on Anxiety in post weaned male and female wistar rats. Pharmacologyonline, 2. pp. 99-122.

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Abstract

Stress in adulthood can have a profound effect on physiology and behavior, but the extent to which prolonged maternal stress affect brain function of offspring when they are adult remains primarily unknown. Controversies exist in literature regarding sexual dimorphism in the effects of prenatal stress on the postnatal cognitive behavioral development. To investigate the effect of prenatal stress on locomotor, exploratory and emotional development, pregnant rats of Wistar strain were subjected to restraint stress from E11 till delivery. Male and female pups born to these stressed rats were subjected to open field test on 21st day of postnatal life. Results were compared with rats of the same age and sex born to control mothers, which were not stressed. The results showed that prenatal maternal restraint stress affected both male and female offsprings during young age. These results suggests that prolonged maternal stress leads to long lasting malfunction of the hippocampus, which extends to and is manifested in adulthood. Prenatally stressed males exhibited higher anxiety levels when compared to the stressed females suggesting that prenatal stress effects are gender- specific.

Item Type: Article
Uncontrolled Keywords: Prenatal stress, open field test, hippocampus
Subjects: Medicine > MMMC Manipal > Anatomy
Medicine > MMMC Manipal > Pathology
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 28 Nov 2011 04:34
Last Modified: 03 Oct 2013 05:59
URI: http://eprints.manipal.edu/id/eprint/1784

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