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Maternal and fetal indicators of oxidative stress during Intrauterine growth retardation (IUGR)

Kamath, Ullas and Rao, Guruprasad and Kamath, Shobha U and Rai, Lavanya (2006) Maternal and fetal indicators of oxidative stress during Intrauterine growth retardation (IUGR). Indian Journal of Clinical Biochemistry, 21 (1). pp. 111-115.

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Abstract

The present study demonstrates the possibility of increased lipid peroxidation and protein oxidation in both maternal and fetal erythrocytes as markers of oxygen radical activity during intrauterine growth retardation. The erythrocyte MDA levels were significantly elevated in mothers of IUGR babies when compared to controls (p<0.01). The endogenous protein damage due to oxidative stress was significantly higher in IUGR mothers when compared to controls (p<0.05). Similarly the proteolytic activity in erythrocyte lysates against oxidatively damaged hemoglobin was significantly increased in mothers of IUGR babies compared to controls (p<0.001). In fetuses born with IUGR, both lipid peroxidation and proteolytic activity were significantly increased when compared to normal newborns (p<0.01). The result of this study indicates that oxidative stress was induced both in IUGR babies and their mothers which is manifested as increased lipid peroxidation and protein oxidant damage.

Item Type: Article
Uncontrolled Keywords: Intrauterine growth retardation, malondialdehyde, proteolytic activity
Subjects: Medicine > KMC Manipal > Biochemistry
Medicine > MMMC Manipal > Biochemistry
Medicine > KMC Manipal > Obstetrics & Gynaecology
Depositing User: KMC Manipal
Date Deposited: 15 Dec 2011 10:55
Last Modified: 15 Dec 2011 10:55
URI: http://eprints.manipal.edu/id/eprint/1817

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