Indicators of oxidative stress in thyroid cancer

Koduru, Bhargav and Tejaswini, * and Thakur, Ajit and Kamath, Shobha U and Shenoy, Rajgopal Kallya and Kamath, Ullas and Reshma, K (2010) Indicators of oxidative stress in thyroid cancer. Indian journal of biochemistry biophysics, 47 (2). pp. 121-123.

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Abstract

Ferric reducing antioxidant power (FRAP), myeloperoxidase (MPO) activity and the levels of protein thiols and carbonyls were estimated in the blood samples of thyroid cancer patients (n = 20) before and after thyroidectomy, as well as in healthy controls (n = 10) to study the extent of damage caused by tumor tissue proliferation-induced oxidative stress and to ascertain that oxidative stress levels drop, when there was no proliferation. A significant decrease (p<0.001) in the levels of serum protein thiols and FRAP as well as a significant increase (p<0.001) in the levels of protein carbonyls and MPO activity in the blood of thyroid cancer patients before surgery was observed as compared to healthy controls. All the parameters studied also showed a significant difference (p<0.001) in their respective levels in thyroid cancer patients, pre- and post-thyroidectomy. These findings present the role of oxidative stress as a pathological implication of thyroid cancer.

Item Type: Article
Subjects: Medicine > KMC Manipal > Biochemistry
Medicine > MMMC Manipal > Biochemistry
Medicine > KMC Manipal > Surgery
Depositing User: KMC EPrints Administrator
Date Deposited: 16 Dec 2011 04:39
Last Modified: 16 Dec 2011 04:39
URI: http://eprints.manipal.edu/id/eprint/1819

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