Shenoy, Revathi P and Bakkannavar, Shankar M and Monappa, Vidya and Bhat, Akshay V and Kumar, Mukesh and Nayak , Vinod C and Kumar, Pradeep G (2011) Identification of Myocardial Infarction in Human Autopsy Population Using TTC. Journal of Pharmaceutical and Biomedical Sciences (JPBMS), 9 (9). pp. 1-4. ISSN 2230 - 7885

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Abstract

Myocardial infarction is the most common cause of sudden death. However the identification of myocardial infarcts at necropsy is difficult. Various methods are being used to detect it. It has been shown that the use of dyes such as nitroblue tetrazolium and 2,3,5 triphenyl tetrazolium chloride (TTC) that identify the dehydrogenase deficient infracted myocardium are largely used. But the studies have been conducted largely in animal models using these dyes. Establishing the utility of these enzyme histochemical tests at autopsy on human cadavers is the need of the hour. We studied the fourty hearts of sudden death cases staining them with TTC and thereafter confirming with histology to know the efficacy of TTC staining. Our results showed that this histochemical test is a reliable method of investigation in sudden death cases.

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