Reversal of Dexamethasone Suppressed Wound Healing with Ethanolic Extract of Leaves of Hyptis Suaveolens (L) POIT

Rajput, Ravindrasingh and Bose, Ujjal and Manjusha, B and Reddy, Sanjeeva and Udupa, AL and Bhat, Vinutha and Rao, Namitha (2011) Reversal of Dexamethasone Suppressed Wound Healing with Ethanolic Extract of Leaves of Hyptis Suaveolens (L) POIT. International Journal of Applied Biology and Pharmaceutical Technology, 2 (1). pp. 307-312. ISSN 0976-4550

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Abstract

The dexamethasone suppressed and normal wound healing effect of ethanolic extract of leaves of Hyptis suaveolens (L) poit. (EEHS) at 400mg/kg and 800mg/kg was studied in Wistar rats. Two wound models viz. incision and excision wounds were used in this study. The parameters studied were breaking strength in case of incision wounds, period of epithelization and wound contraction in case of excision wound. The dexamethasone treated group showed a significant (P<0.05) reduction in the wound breaking strength in incision type of wound model and significant increase in epithelization period and reduction in percentage of wound contraction in excision type of wound model as compared to control group. Extract treated groups showed significant (P<0.05) improvement in all the wound healing parameters of incision and excision wound models as compared to control. In incision wound model, Co administration of EEHS at both the dosage levels with dexamethasone had significantly (P<0.05) increased the wound breaking strength as compared to dexamethasone only treated group and was seen more at dosage level of 400mg/kg. Similarly, in excision wound model, there was significant improvement (P<0.05) in both the parameters when EEHS was co administered with dexamethasone as compared to dexamethasone only treated group but improvement was more at dosage level of 800mg/kg.

Item Type: Article
Uncontrolled Keywords: yptis suaveolens, wound healing, dexametasone, epithelization period, wound contraction, wound breaking strength, Incision wound, Excision wound
Subjects: Medicine > KMC Manipal > Biochemistry
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC EPrints Administrator
Date Deposited: 16 Dec 2011 09:51
Last Modified: 16 Dec 2011 09:51
URI: http://eprints.manipal.edu/id/eprint/1825

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