Rajput, Ravindrasingh and Bose, Ujjal and Barma, Manjusha and Udupa, Laxminarayana A and Bhat, Vinuta and Rao, Namita (2010) Evaluation of hyptis suaveolens for anti-oxidant property and reversal of dexamethasone supression in dead space wound model. Int J Pharm Sci Bio, 1 (3). pp. 141-144. ISSN 2229-3604

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Abstract

Background and objectives: Hyptis suaveolens belongs to the family of Labiatae; an aromatic annual shrub which has been used for wound healing in traditional medicine in India. Objective of the study was to determine dex-amethasone suppressed and normal dead space wound healing effect and anti-oxidant property of ethanolic extract of leaves of Hyptis suaveolens (EEHS) at 400mg/kg and 800mg/kg in Wistar rats. Methods: Dead space wound model was used in this study. The parameters studied were granulation tissue breaking strength (g) by constant water flow technique and hydroxyproline content (mg/100 gm). Anti-oxidant parameters like catalase, superoxide dismutase (SOD), glutathione synthetase, and net protein content were also estimated using the granulation tissue. Results: EEHS treated groups showed significant (P<0.05) improvement in granulation tissue breaking strength and hydroxyl proline content as compared to control. Co-administration of EEHS at both the dosage levels with dexamethasone had significantly (P<0.05) improved the granulation tissue breaking strength and hydroxyl proline and protein content as compared to dexamethasone alone treated group. There was significant improvement (P<0.05) in all the estimated anti-oxidant parameters with EEHS at two dosage levels (400mg/kg and 800mg/kg) as compared to control group. Conclusion: In this study, EEHS has shown to have anti-oxidant property and also significantly improved the wound healing and effectively reversed the dexamethasone suppressed wound healing in dead space wound model in wistar rats.

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