Serum Albumin and its Relationship with Glutathione Levels in Patients with Brain Tumor

Nayal, Bhavna and Goud, Manjunatha BK and Raghuveer, CV and Shetty, Jeevan K and Devi, Sarsina and Deepa, K and Devaki, RN (2011) Serum Albumin and its Relationship with Glutathione Levels in Patients with Brain Tumor. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2 (1). pp. 780-784. ISSN 0975-8585

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Abstract

Present study was carried out to compare the levels of serum albumin and glutathione in patients’ with brain tumor and healthy controls and to know the relationship between glutathione and serum albumin.The study was carried out in 30 patients with brain tumor and 30 healthy age matched controls. Glutathione levels were measured pectrophotometrically using Beutler’s method. Serum albumin and total protein were estimated using automated analyzer and serum globulin was calculated by subtracting albumin from total protein.There was significant decrease in levels of serum albumin, globulin and glutathione (p<0.001) in brain tumor patients compared to healthy controls. On applying Pearson’s correlation serum albumin levels correlated positively with glutathione (p<0.01, r = 0.777).Decreased albumin levels reduce the available protein bound thiols, along with decrease in glutathione levels which may further enhance the oxidative stress in patients with brain tumor. Keywords: Glutathione, Albumin, Oxidative stress, Brain tumor

Item Type: Article
Subjects: Medicine > KMC Manipal > Biochemistry
Medicine > MMMC Manipal > Biochemistry
Medicine > MMMC Manipal > Pathology
Depositing User: KMC Manipal
Date Deposited: 21 Dec 2011 05:04
Last Modified: 21 Dec 2011 05:04
URI: http://eprints.manipal.edu/id/eprint/1862

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