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Total Thiols and MDA Levels in Patients with Acute Myocardial Infarction Before and After Reperfusion Therapy

Babu, Suresh and Shetty, Jeevan K and Prakash, Mungli (2010) Total Thiols and MDA Levels in Patients with Acute Myocardial Infarction Before and After Reperfusion Therapy. Online Journal of Health and Allied Sciences, 9 (3). pp. 1-4. ISSN 0972-5997

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Abstract

Background: Reactive oxygen species have been implicated in the pathogenesis of ischemic and reperfusion injury. In the current work we have measured malondialdehyde (MDA), total thiols, total CK, CK-MB and AST in ECG proven acute myocardial infarction (AMI) patients immediately after admission and 24 hours after administration of thrombolytic agent streptokinase, and in healthy controls. Methods: Blood samples from 44 AMI patients and 25 age and sex matched healthy controls were obtained and analyzed for MDA, total thiols using spectrophotometric methods and cardiac enzymes CK, CK-MB and AST using automated analyzer. Results: We have found significant increase in MDA, CPK, CK-MB, AST (p< 0.001) and significant decrease in total thiols (p<0.001) in AMI patients after thrombolytic therapy compared to values at admission, and healthy controls. MDA correlated negatively with total thiols (r = - 0.333, p<0.05) and positively with CKMB (r = 0.491, p<0.01) in AMI patients after thrombolytic therapy. Conclusions: Reperfusion following thrombolytic therapy increases reactive oxygen species with concomitant decrease in antioxidant total thiols.

Item Type: Article
Uncontrolled Keywords: MDA, Total thiols, Myocardial infarction, Reperfusion injury
Subjects: Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Manipal
Date Deposited: 21 Dec 2011 05:07
Last Modified: 21 Dec 2011 05:07
URI: http://eprints.manipal.edu/id/eprint/1881

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