Glutathione S-Transferase Activity and Total Thiol Status in Chronic Alcohol Abusers Before and 30 days after Alcohol Abstinence

Muttigi, Manjunatha S and Prabhu, Lakshmi S and Kedage, Vivekananda and Prakash, Mungli and Shetty, Jeevan K and Virupaksha, Devaramane and Bhandary, Panambur V (2009) Glutathione S-Transferase Activity and Total Thiol Status in Chronic Alcohol Abusers Before and 30 days after Alcohol Abstinence. Online Journal of Health and Allied Sciences, 8 (1). pp. 1-5.

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Abstract

Background: Glutathione S Transferase (GST) has been involved in detoxification process in the liver and its activity has been shown to be increased in alcohol abusers. In the current work we measured the GST activity, total thiol status, AST, ALT, and direct bilirubin in chronic alcohol abusers before and 30 days after alcohol abstinence and lifestyle modification. Methods: Serum and urine GST activity and total thiol status were determined using spectrophotometric methods and serum transaminases were determined using clinical chemistry analyzer. Results: We found,significant increase in serum and urine GST (p<0.001), AST (p<0.001), ALT (p<0.001), and decrease in total thiol status (p<0.001) in chronic alcohol abusers. GST activity significantly decreased (p<0.001) and total thiol status were improved significantly (p<0.001) 30 days after alcohol abstinence and lifestyle modification. Conclusion: This study provides preliminary data to suggest the role of GST as prognostic indicator of alcohol abstinence with possible trend towards an improvement in liver function.

Item Type: Article
Uncontrolled Keywords: Glutathione S Transferase; Total thiols; Alcoholic liver disease; Alcohol abstinence
Subjects: Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Manipal
Date Deposited: 21 Dec 2011 04:42
Last Modified: 17 Oct 2013 10:04
URI: http://eprints.manipal.edu/id/eprint/1884

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